{"id":1911,"date":"2025-09-21T09:00:38","date_gmt":"2025-09-21T04:00:38","guid":{"rendered":"https:\/\/psbkgnews.com\/en\/?p=1911"},"modified":"2025-09-19T17:34:22","modified_gmt":"2025-09-19T12:34:22","slug":"gut-bacteria-liver-cancer","status":"publish","type":"post","link":"https:\/\/psbkgnews.com\/en\/1911\/gut-bacteria-liver-cancer\/","title":{"rendered":"First 60-Minute Cancer Treatment Centre Launched in Pakistan"},"content":{"rendered":"<h3><strong>Gut Bacteria Linked to Deadly Liver Cancer<\/strong><\/h3>\n<p><a style=\"color: black; text-decoration: none;\" href=\"https:\/\/psbkgnews.com\/en\">Latest News<\/a>: Scientists have discovered that harmful gut bacteria could be driving the rise in cases of deadly liver cancer. The study highlights a new mechanism by which gut microbes influence liver fat and sugar production, raising the risk of liver disease.<\/p>\n<h4><strong>Beyond Alcohol: Diet and Liver Health<\/strong><\/h4>\n<p>While excessive alcohol intake is a well-known cause of liver disease, experts warn that poor diet and factors that increase fat in the liver can also significantly raise risk. Liver disease is the only major illness in which death rates have steadily increased, quadrupling over the past 50 years, according to the British Liver Trust.<\/p>\n<h4><strong>Canadian Study Uncovers Key Molecule<\/strong><\/h4>\n<p>Researchers in Canada have identified a molecule produced by gut bacteria that triggers the liver to generate excess sugar and fat. Published in Cell Metabolism, the study suggests that targeting this microbial source could help control blood sugar and reduce liver damage, particularly in high-risk obese patients.<\/p>\n<h4><strong>New Approach to Treating Liver Disease<\/strong><\/h4>\n<p>Professor Jonathan Schetzer, lead author from <a style=\"color: black; text-decoration: none;\" href=\"https:\/\/www.mcmaster.ca\/\">McMaster University<\/a>, explained: \u201cInstead of targeting hormones or the liver directly, we\u2019re intercepting a microbial fuel source before it can do harm.\u201d The study builds on knowledge from the Cori cycle, demonstrating how gut bacteria influence liver metabolism through a lesser-known molecule called D-lactate.<\/p>\n<h4><strong>Obesity and D-Lactate<\/strong><\/h4>\n<p>The study found that obese individuals have higher levels of D-lactate, primarily from gut microbes, which raises blood sugar and liver fat more dramatically than the commonly known L-lactate. Researchers developed a biodegradable \u201cgut substrate trap\u201d to bind D-lactate and prevent its absorption.<\/p>\n<h4><strong>Promising Results in Mice<\/strong><\/h4>\n<p>Mice fed the gut trap showed lower blood glucose levels, improved insulin resistance, and reduced liver inflammation and fibrosis, without changes to diet or body weight. These findings point to a potential new way to treat metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease.<\/p>\n<h4><strong>MASLD: A Growing Public Health Concern<\/strong><\/h4>\n<p>MASLD affects roughly 1 in 5 people in the UK and is caused by fat accumulation in the liver, leading to inflammation and scarring over time. Untreated, it can progress to cirrhosis, liver failure, or cancer, with obese individuals and type 2 diabetics at higher risk.<\/p>\n<h4><strong>Awareness and Early Intervention<\/strong><\/h4>\n<p>Professor Philip Newsome of King\u2019s College London emphasized that many people are unaware they have MASLD until serious damage occurs. Fat accumulation and uncontrolled blood sugar, not just alcohol, can lead to severe liver scarring. Symptoms, if present, may include fatigue, malaise, or discomfort in the upper right abdomen.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gut Bacteria Linked to Deadly Liver Cancer Latest News: Scientists have discovered that harmful gut bacteria could be driving the rise in cases of deadly liver cancer. The study highlights a new mechanism by which gut microbes influence liver fat and sugar production, raising the risk of liver disease. Beyond Alcohol: Diet and Liver Health [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":1926,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[11,14],"tags":[],"class_list":["post-1911","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-more","category-news"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v24.2 (Yoast SEO v27.1.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Gut Bacteria Identified as Key Driver of Deadly Liver Disease | PSBKG NEWS<\/title>\n<meta name=\"description\" content=\"Harmful gut bacteria linked to deadly liver cancer. 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